Risk Factors Update Summary

• Recent cross-border data transfer compliance requirements in China may impose additional costs of doing business.
• Additional tax liabilities may arise from ongoing tax disputes, OECD minimum corporate tax rate, and new tax legislation, impacting profitability.
• Increased focus on ESG practices globally may lead to material adverse effects if not met.
• Anticipated tax liabilities from the 2017 Tax Act provisions going into effect in 2026 may adversely affect profitability.
• Potential inability of governments to sustain high fiscal spending due to financial pressures.
• Sales and operations may be negatively impacted by competition, consolidation of private payers, and certain provisions of the 2017 Tax Act.
• Global macroeconomic challenges may have an extended duration, impacting the economy.
• The IRA legislation introduces drug pricing controls and Medicare redesign, likely impacting sales and business operations.
• Increased operating expenses due to rising energy costs and geopolitical events may affect financials.
• Potential changes in tax laws, including the OECD agreement, may result in tax increases affecting the company's tax liabilities.
• Cybersecurity risks have increased due to remote working arrangements, potential data breaches, and system vulnerabilities.
• Various states have enacted or proposed laws impacting drug pricing, Medicaid, and the 340B Drug Pricing Program, potentially affecting the company's operations.