Risk Factors Update Summary

• Addition of "or debt securities" to risk factors, highlighting potential loss of investment in common shares or debt securities.
• Ongoing geopolitical conflicts may heighten risks, including market value decline and economic consequences.
• Inclusion of "Current" before "market" and "economic conditions," emphasizing the impact of current conditions on business growth.
• Increase in outstanding debt from $2.3 billion to $3.488 billion, impacting financial obligations and interest rate risk.
• Acquisition of XIIDRA and other assets, with potential integration challenges and impact on market value.
• Sales revenue from Russia decreased from 4% to 3%, potentially impacting market value.
• Change from "indicative" to "representative" regarding historical financial information, enhancing its relevance.
• Transition to a new Chairman and CEO, Brent Saunders, with potential operational disruptions and impact on market value.
• Effective tax rates may increase due to global minimum tax implementation, affecting financials.
• Appointment of new executive officers and key employees, potentially affecting operations and market value.