Risk Factors Update Summary

• Accumulated deficit decreased from $259 million to $238 million, indicating improved financial position.
• Cash and cash equivalents decreased from $209 million to $141 million, impacting liquidity.
• New rules and regulations could impact patent enforcement, with potential significant damages. This might result in financial losses.
• Additional capital of $45 million required before December 31, 2024, to fund operations.
• The addition of maintaining patents could increase costs and divert resources, affecting financial condition.
• Increased need for capital due to ongoing operating losses and negative cash flows.
• The potential loss of patent protection could lead to significant financial implications and affect related patents.
• Seeking capital through debt and equity to fund research, development, and operations.
• Increased risks to information technology systems and data due to remote workforce actions.
• Potential impact on business from economic events like the crisis in Ukraine and Israel-Hamas war.
• Exchange rate fluctuations may affect financial statements prepared in euros, impacting financial condition.
• Uncertainty regarding ability to continue as a going concern due to available cash projections.
• Data privacy regulations outside the US could complicate compliance efforts, leading to fines.
• Delisting could negatively impact ADS price, limit capital raising, and reduce investor confidence.