Risk Factors Update Summary

• Adverse global economic conditions could negatively impact business, financial condition, and liquidity.
• Financial market volatility may affect access to capital and future cost of capital.
• Changes in stock ownership may impact the utilization of net operating loss carryforwards.
• Failure to comply with Nasdaq's Minimum Bid Price Requirement of $1.00/share could lead to delisting.
• Worldwide economic and social instability could adversely affect business and operating results.
• Failure to obtain regulatory approval for product candidates could harm commercial prospects.
• Reduced liquidity and potential loss of investor confidence if common stock is delisted.
• Choice of forum provision in bylaws may limit stockholders' ability to bring claims.
• Failure to raise additional capital may hinder future capital raising activities.
• Increased competition in the obesity treatment market poses a challenge for product success.
• Market value conditions for public float and annual revenue thresholds for reporting requirements changed.
• Designation of the Court of Chancery of the State for derivative actions and proceedings.