Company – Scrape Financial
Risk Factors Summary

Risk Factors Update Summary

  • Net losses increased from $164 million to $722 million, impacting future funding requirements significantly.
  • Addition of tamibarotene commercial companion diagnostic by Qiagen for RARA overexpression. This may enhance revenue.
  • Accumulated deficit rose from $558 million to $722 million, affecting financial stability.
  • Changes in tax laws: Federal and state net operating loss carryforwards increased to $348.7 million and $349.0 million respectively.
  • Development focus shifted to tamibarotene, halting investment in SY-2101 and SY-5609.
  • Introduction of the Windsor Framework changing Human Medicines Regulations 2012 impacting UK market approvals.
  • Strategic realignment to prioritize tamibarotene for HR-MDS and AML treatment, ceasing SY-2101 development.
  • Seeking partnerships for oncology discovery programs, including CDK12, to enhance commercialization prospects.
  • Dependence on Qiagen for companion diagnostic test development, with potential commercialization risks.
  • Lack of sales, marketing, and distribution infrastructure may hinder commercial launch success.

Full Text Changes in Most Recent 10-K

Intended use: review the highlighted statements. These are additions to the risk factors disclosure in the most recent 10-K filing compared to the previous 10-K filing. Deleted and moved text is less important and is shown for context.

To view the full company filings, click on the following link to be taken to the SEC EDGAR database landing page for the company: https://www.sec.gov/edgar/browse/?CIK=1556263&owner=exclude

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